Effect of Extracts of Cloves (Syzygium Aromaticum) on Hepatic Cell Damage and Oxidative Stress Caused by Diabetes in Adult Rats

Authors

  • Ghaderpour, Saber Department of Physiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.Student Research Committee, North Khorasan University of Medical Sciences, Bojnord, Iran.
  • Halimi, Monireh Department of Pathology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Maroufi, Parham Department of Orthopedics, Shohada Medical Research, School of Medicine, Tabriz University of Medical Sciences,Tabriz, Iran.
  • Pourlak, Tala Department of Pathology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Pourlak, Tannaz Aging Research Institute, Tabriz University of Medical Sciences Tabriz, Iran.
  • Shokoohi, Arefeh Student Research Committee, North Khorasan University of Medical Sciences, Bojnord, Iran.
Abstract:

Aims: In this study, we investigated the effect of clove extract (Syzygium aromaticum) on liver cell damage and oxidative stress caused by diabetes in adult rats. Methods & Materials: For this study, 28 female rats were collected and divided into four groups: A: Control group; B: Diabetic Control group (DC) which received 20% glycerol dissolved in normal saline as carriers; C: Diabetic rats (DSA) treated with cloves hydroalcoholic extract (4 mg/kg); d) diabetic rats (DG) treated with glibenclamide (5 mg/kg) as a standard drug. Findings: The fasting blood sugar and serum triglyceride levels in the DC group increased significantly compared to the control group (P<0.05). In DC, DG, and DSA groups, high-density lipoprotein, and serum insulin levels decreased significantly compared to the control group (P<0.05). Also, in DG and DSA groups, high-density lipoprotein and serum insulin levels increased significantly compared to the DC group. Conclusion: Cloves can affect fasting blood sugar, serum insulin levels, serum fat profile levels, and prevent liver tissue damage in diabetic rats caused by streptozotocin.

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Journal title

volume 26  issue 4

pages  432- 447

publication date 2020-09

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